Acknowledgement:

The CellDesigner file that is used as a test was developed by K. Oda and H. Kitano from the Systems Biology Institute in Tokyo, Japan.

This is the paper that describes the diagram:

Oda,K. & Kitano,H. (2006) A comprehensive map of the toll-like receptor signaling network. 
Mol Syst Biol, 2, 10.1038/msb4100057. Available at: http://dx.doi.org/10.1038/msb4100057